Article · Volume 12, Issue 46S · pp. S228–S230

Life Span and Motility Effects of Ethanolic Extracts from Sophora moorcroftiana Seeds on Caenorhabditis elegans

Xin Li², Junxian Han², Rongyan Zhu², Rongrong Cui², Xingming Ma^2,3, Kaizhong Dong⁴

¹Department of Immunology, School of Basic Medical Sciences, China.
²Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, China.
³Department of Microbiology, Medical College, Northwest University for Nationalities, Lanzhou 730000, China.

Abstract

Background: Sophora moorcroftiana is an endemic shrub species with a great value in folk medicine in Tibet, China. In this study, relatively little is known about whether S. moorcroftiana is beneficial in animals’ nervous system and life span or not.Materials and Methods: To address this question, under survival normal temperature (25°C), S. moorcroftiana seeds were extracted with 95% ethanol, and Caenorhabditis elegans were exposed to three different extract concentrations (100 mg/L, 200 mg/L, and 400 mg/mL) from S. moorcroftiana seeds.Results: The 95% ethanolic extracts from S. moorcroftiana seeds could increase life span and slow aging‑related increase in C. elegans and could not obviously influence the motility of C. elegans.Conclusion: Given these results by our experiment for life span and motility with 95% ethanolic extracts from S. moorcroftiana seeds in C. elegans, the question whether S. moorcroftiana acts as an anti‑aging substance in vivo arises.

Keywords: Anti‑aging; Caenorhabditis elegans; motility; Sophora moorcroftiana

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