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PM · Lens · Anti-nociceptive Effect of 7-methoxy Coumarin from Eupatorium Triplinerve vahl (Asteraceae)

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Article · Volume 13, Issue 49 · pp. 81–4

Anti-nociceptive Effect of 7-methoxy Coumarin from Eupatorium Triplinerve vahl (Asteraceae)

Binoy Varghese Cheriyan1, Parimala Kadhirvelu2, Jagan Nadipelly3, Jaikumar Shanmugasundaram2, Vijaykumar Sayeli4, Viswanathan Subramanian2

  1. 1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai, India.
  2. 2Department of Pharmacology, Meenakshi Medical College and Research Institute, Enathur, Kanchipuram, India.
  3. 3Department of Pharmacology, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak, Telangana, India.
  4. 4Department of Pharmacology, Mamata Medical College and Hospital, Rotary Nagar, Khammam, Telangana, India.

Abstract

Aim: To evaluate the anti-nociceptive activity of 7-methoxy coumarin isolated from ethyl acetate fraction of the alcoholic extract of Eupatorium triplinerve Vahl.Materials and Methods: The shade dried leaves of E. triplinerve were extracted with ethyl alcohol and the extract was condensed. This extract was fractionated with n-hexane, ethyl acetate, and n-butanol. The ethyl acetate fraction was subjected to column chromatography which yielded a crystalline compound-A, which was investigated for spectral characteristics. Pharmacological studies: The isolated compound-A was subjected to behavioral studies and anti-nociceptive evaluation in mice by acetic acid induced writhing and formalin induced nociception.Results: The spectral studies indicated that the structure of compound-A complies with 7- methoxy coumarin. Pre-treatment with 7-methoxy coumarin reduced the number of abdominal constrictions in mice and decreased the time spent in paw licking and biting response in formalin assay. There were no significant behavioral changes.Conclusion: A dose dependent anti-nociceptive action of 7- methoxy coumarin was revealed by the present experiments which support the traditional use of E. triplinerve in pain and inflammatory disorders.

Keywords: anti-nociception; ayapanin; eupatorium triplinerve (E. triplinerve); herniarin; 7-methoxy coumarin

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