Article · Volume 13, Issue 50 · pp. 236–239
Evaluation of Herb–Drug Interactions of Hovenia dulcis Fruit Extracts
Jong Suk Park1, Shaheed Ur Rehman1, In Sook Kim1, Min Sun Choi1, Chun-Soo Na2, Hye Hyun Yoo1
- 1Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.
- 2Lifetree Biotech Co., Ltd., Suwon, Gyeonggi-do, Republic of Korea.
Abstract
Background: Hovenia dulcis (Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including H. dulcis fruit extracts, to be taken with prescription drugs.Objective: In this study, possible food–drug interactions involving H. dulcis fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity.Material and Methods: The water extract of H. dulcis fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry.Results: H. dulcis fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested.Conclusion: This result suggests that H. dulcis fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes.
Keywords: Hovenia dulcis; Herb–drug interactions; CYP450; inhibition
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