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PM · Lens · Determination and Tissue Distribution Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodes Rhizome

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Article · Volume 13, Issue 51 · pp. 413–417

Determination and Tissue Distribution Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodes Rhizome

Yang-Zhi Liu1, Yu-Qiang Liu1, Rui Jia1, Jun Li2, Xiao-Wen Chang1, Chen-Xi Xu1, Qian Cai1

  1. 1Department of Medicine, Liaoning University of Traditional Chinese Medicine, China.
  2. 2Department of Medicine, Dalian Institute for Drug Control, Dalian, China.

Abstract

Background: Atractylodis rhizoma is one of the most often used drugs in traditional Chinese medicine. Stir frying with wheat bran is the most common processing method. To clarify the principle of processing, an experiment was carried out to compare the tissue distribution of typical constituent after oral administration of raw A. rhizoma and processed ones.Objective: To compare the tissues distribution of atractylodin after oral administration of raw and processed A. rhizoma and clarify the processing principle of A. rhizoma.Materials and Methods: High‑performance liquid chromatogram with ultraviolet detection was developed and validated for the determination of atractylodin in rat tissues.Results: The atractylodin in raw and processed A. rhizoma was distributed in all tissues involved in this study.Conclusions: The concentration of atractylodin in it is the highest in the stomach and small intestine.

Keywords: Atractylodin; Atractylodis rhizoma; crude and processed; tissue distribution

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