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PM · Lens · The Standardized Extract of Limonium tetragonum Alleviates Chronic Alcoholic Liver Injury in C57BL/6J Mice

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Article · Volume 14, Issue 53 · pp. 58–63

The Standardized Extract of Limonium tetragonum Alleviates Chronic Alcoholic Liver Injury in C57BL/6J Mice

Na-Hyun Kim1, Jeong-Doo Heo2, Jung-Rae Rho2, Min Hye Yang3, Eun Ju Jeong4

  1. 1Gyeongnam Department of Environment and Toxicology, Korea Institute of Toxicology, Gyeongnam 52834, Republic of Korea.
  2. 2Department of Oceanography, Kunsan National University, Jeonbuk 54150, Republic of Korea.
  3. 3College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.
  4. 4Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.

Abstract

Background: In traditional folk medicine, Limonium tetragonum is used in the treatment of uterine hemorrhage, tinnitus, and oligomenorrhea.Objective: This study aimed to identify the therapeutic effect of L. tetragonum EtOAc extract (EALT) on liver of mice with chronic alcohol poisoning.Materials and Methods: C57BL/6J mice were administered 100 mg/kg of EALT with a single binge ethanol/Lieber‑DeCarli liquid diet for 8 weeks.Results: The chronic‑binge ethanol diet induced a significant increase in liver marker enzyme activities. Coadministration of EALT reversed the elevation of serum total cholesterol and triglyceride as well as aspartate aminotransferase and alanine aminotransferase due to chronic alcohol consumption. Histologic findings including markedly attenuated fat accumulation in hepatocytes were observed in EALT‑treated mice. EALT supplementation prevented alcoholic liver injury through attenuation of inflammatory mediators such as toll‑like receptor‑4, cytochrome P4502E1, and cyclooxygenase‑2, and inflammatory cytokine interleukin‑6.Conclusion: Results provided direct experimental evidence for the hepatoprotective effect of EALT in the NIAAA mouse model. Therapeutic attempts with the L. tetragonum extract might be useful in the management of alcoholic liver disease.

Keywords: Alcoholic liver disease; chronic‑binge ethanol‑fed mice; inflammatory mediators and cytokines; Limonium tetragonum; liver marker enzymes

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