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PM · Lens · A Novel Compound Lup‑20 (29)‑ene‑3α,6β‑diol Identified in Petroleum Ether Extract of Diospyros melanoxylon Roxb. Leaves and to Reveal Its Antidiabetic Activity in Rats

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Article · Volume 14, Issue 55S · pp. S245–S248

A Novel Compound Lup‑20 (29)‑ene‑3α,6β‑diol Identified in Petroleum Ether Extract of Diospyros melanoxylon Roxb. Leaves and to Reveal Its Antidiabetic Activity in Rats

Anil Kumar Sharma1, Tek Chand Sharma2, Ruchi Singh2,3, Pratibha Payal2, Rajnish Gupta4,5, Mahesh Chandra Sharma2

  1. 1Department of Chemistry, Jagan Nath University.
  2. 2Department of Chemistry, Natural Products Laboratory, University of Rajasthan.
  3. 3Department of Chemistry, The IIS University.
  4. 4Department of Zoology, University of Rajasthan, Jaipur, Rajasthan.
  5. 5Department of Neurobehavioral Toxicology, ICMR‑NIOH, Ahmedabad, Gujarat, University, India.

Abstract

Background: Diospyros melanoxylon Roxb. belongs to the family Ebenaceae and its leaves show diuretic, carminative, laxative, and styptic bioactivities.Objective: The objective of this study was to give a direction for future investigators to carry out research on phytochemistry and develop a potent antidiabetic agent.Materials and Methods: Petroleum ether extract of D. melanoxylon Roxb. leaves was chromatographed over silica gel column. Isolated compounds were elucidated on the basis of different spectroscopic techniques (mass spectrometry, infrared, 1H, 13C nuclear magnetic resonance, and distortionless enhancement by polarization transfer). Antidiabetic activity of lup‑20 (29)‑ene‑3,6 β‑diol was evaluated in streptozotocin diabetic rats.Results: A novel compound, lup‑20 (29)‑ene‑3,6 β‑diol (6), was identified along with 11 known natural compounds, namely, lupeol (1), ceryl alcohol (2), octacosanol‑1 (3), hentriacontanol‑1 (4), β‑sitosterol (5), diospyrin (7), 3‑methoxydiospyrin (8), betulin (9), ursolic acid (10), betulinic acid (11), and oleanolic acid (12). Further administration of lup‑20 (29)‑ene‑3,6 β‑diol significantly improved the diabetes‑induced oxidative stress.Conclusion: Investigation of this novel compound plays an important role in the field of drug development.

Keywords: Antidiabetic; biological activities; Diospyros; Ebenaceae; phytochemicals; streptozotocin

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