Article · Volume 14, Issue 56 · pp. 328–32
Immunostimulant Activity of Bergenia Extracts
Lenka Tumová1, Helena Hendrychová2, Doris Vokurková2
- 1Department of Pharmacognosy, Faculty of Pharmacy Hradec Králové, Charles University, Hradec Králové, Czech Republic.
- 2Departmen of Clinical Immunology and Allergology, Faculty of Medicine and University Hospital, Charles University, Sokolská, Hradec Králové, Czech Republic.
Abstract
Background: Bergenia species contain various therapeutically important compounds such as phenolic compounds‑arbutin, bergenin, tannins, gallic acid, flavonoids, minerals, and many others. Bergenia plants show antibacterial, antiviral, anticancer, antidiabetic, diuretic and immunostimulant activities.Materials and Methods: Bergenia leaf extracts from Bergenia crassifolia, Bergenia ciliata, and Bergenia x ornata on lymphocyte activation using flow cytometry method were investigated. Their activation was then monitored with the help of the increasing fluorescence intensity.Results: By activating of cells, there has been an increase in the amount of the established antibodies. Bergenia extracts significantly stimulated the expression of CD69 on lymphocytes in the final concentration of 3.13 and 6.25 mg/ml. The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ.Conclusion: The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ.
Keywords: Bergenia; immunostimulant activity; lymphocytes
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