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PM · Lens · Antiproliferative and Antiangiogenic Effects of Zerumbone from Zingiber zerumbet L. Smith in Sprague Dawley Rat Model of Hepatocellular Carcinoma

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Article · Volume 15, Issue 61 · pp. 277–282

Antiproliferative and Antiangiogenic Effects of Zerumbone from Zingiber zerumbet L. Smith in Sprague Dawley Rat Model of Hepatocellular Carcinoma

Nozlena Abdul Samad2,3, Ahmad Bustamam Abdul3, Heshu Sulaiman Rahman4,5,6, Rasedee Abdullah7, Tengku Azmi Tengku Ibrahim7, Hemn Hassan Othman8,9

  1. 1Integrative Medicine Cluster, Sains@BERTAM, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
  2. 2Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia.
  3. 3Department of Clinic and Internal Medicine and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
  4. 4Department of Medical Laboratory Sciences, College of Science, Komar University of Science and Technology, Sulaimani City, Iraq.
  5. 5Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
  6. 6Departments of Microbiology and Pathology and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
  7. 7Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  8. 8Anatomy and Pathology, College of Veterinary Medicine, University of Sulaimani.

Abstract

Aims: This study aimed to investigate the in vivo antiproliferative and antiangiogenesis effects of ZER using rats with diethylnitrosamine‑induced hepatocellular carcinoma (HCC).Materials and Methods: The antiproliferative and anti‑angiogenesis effects of ZER were determined using the hepatosomatic index, vascular endothelial growth factor (VEGF) immunoassay, terminal deoxynucleotidyl transferase dUTP nick end labeling assay, histopathology, and immunohistochemistry analysis.Results: Nontreated rats with HCC had higher median liver weight than those treated with ZER or suramin. The expression of VEGF, matrix metalloprotease, and Ki‑67 that were high in nontreated HCC rats was down‑regulated with ZER or suramin treatments. Statistical Analysis Used: Statistical analyses were performed using the Statistical Package for Social Science version 21.0 (SPSS Inc, IBM, Maryland, USA). The data were expressed as the mean ± standard deviation and analyzed using a one‑way analysis of variance. P < 0.05 was considered statistically significant.Conclusion: ZER has the potential to be developed as the pro‑apoptotic and antiangiogenic agent in the treatment of HCC.

Keywords: Active compound; angiogenic biomarkers; antiproliferative; hepatocellular carcinoma; in vivo study; natural product

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