Article · Volume 15, Issue 61 · pp. 322–326
Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea
Lilian Carneiro Dos Anjos1, Jacqueline Coimbra Gonçalves1, Bruna Ramos De Araujo1, Marcia Renata Mortari1
- 1Department of Physiological Sciences, Neuropharmacology Laboratory, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Abstract
Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities.Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of <em>Crotalaria pallida</em> Aiton.Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model. The antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC).Results: The methanolic extract of <em>C. pallida</em> showed significant anti-inflammatory activity in a dose-dependent manner. The extract also exhibited potent antioxidant activity with an IC50 value of 45.23 μg/mL in DPPH assay. The TPC was found to be 124.5 mg gallic acid equivalent/g of extract.Conclusion: The results suggest that <em>C. pallida</em> possesses significant anti-inflammatory and antioxidant properties, which could be attributed to the presence of phenolic compounds.
Keywords: Antinociception; pain; peptides; toxin; wasp venom
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