jrnls.org logo
Submit

BROWSE ALL JOURNALS

Type 2 letters to search all 19 journals

SEE ALL 19 JOURNALS
Pharmacognosy MagazineNOW IN
Back

PM · Lens · Nutritional Value and Nephrotoxicity Effect of Dillenia pentagyna Fruit on Alloxan‑induced Diabetic Rats

PDF

Article · Volume 15, Issue 62S · pp. S118–S122

Nutritional Value and Nephrotoxicity Effect of Dillenia pentagyna Fruit on Alloxan‑induced Diabetic Rats

Ranjeet Kumar Yadav1, Arpit Azad2, S. K. Srivastava1, B. Sharma3, Mahesh Pal2

  1. 1Department of Biochemistry and Biochemical Engineering, Sam Higginbottom University of Agriculture Technology and Sciences, Allahabad, India.
  2. 2Division of Phytochemistry, CSIR‑National Botanical Research Institute, Lucknow, Uttar Pradesh, India.
  3. 3Department of Biochemistry, School of Sciences, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

Abstract

Objective: The proximate parameters and high‑performance thin layer chromatography (HPTLC) analysis in the same plant of D. pentagyna of four‑time harvest stage during the maturation of fruits were studied and also the antihypoglycemic activity of hydroalcoholic extract of D. pentagyna fruit.Materials and Methods: The proximate compositions were determined by measuring the amount of water removed from the food AOAC method and the chemical fingerprinting was carried out by HPTLC method. An acute oral toxicity study was carried out in healthy male Wister rats (110 g). The dose was finally made to 200 and 400 mg/kg body weight for oral administration after the LD50 estimation.Results: The most phenolic concentration was continuously decrease with during the maturation of fruits. After 21 days of treatment, level of blood glucose, as well as albumin, protein, creatinine, urea, and uric acid were significantly decreased when compared with the diabetic control. Hydroalcoholic (80% alcohol to 20% DW) extracts will be subjected to further extensive studies to isolate and identify their active constituents which are useful for against antidiabetic.Conclusion: D. pentagyna fruit could act as a source of functional compounds for the control of diabetes mellitus.

Keywords: Diabetic nephropathy; Dillenia pentagyna; high‑performance thin layer chromatography; hyperglycemic; medicinal plants

The full text of this article is available as a PDF. Open the PDF.