Article · Volume 15, Issue 62S · pp. S34–S37
In vitro Antileishmanial Activity of Methanolic Extracts for Some Selected Medicinal Plants
Ahmed Gomaa Gomaa Darwish2,3, Mamdouh Nabil Samy3,4, Sachiko Sugimoto3, Katsuyoshi Matsunami3, Hideaki Otsuka3,5
- 1Department of Biochemistry, Faculty of Agriculture, Minia University.
- 2Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University.
- 3Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
- 4Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women’s University, Hiroshima, Japan.
Abstract
Objective: The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants; ten well‑known medicinal plants cultivated and growing under African environmental conditions were studied.Materials and Methods: The methanolic extracts of these plants were screened for their antileishmanial activity against Leishmania major using 3‑(4.5‑dimethylthiazol‑2yl)‑2.5‑diphenyltetrazolium bromide assay.Results: The methanol extract of Colchicum autumnale and Alpinia officinarum showed potent antileishmanial activity at inhibition% value of 98.29% ± 0.75% and 97.25 ± 1.63%, respectively, while Silybum marianum exhibited inhibition% value of 90.97% ± 1.13%, compared with the standard amphotericin B (89.31% ± 2.08%).Conclusion: Considering these results, medicinal plants from African environment could constitute a developer source for antileishmanial compounds.
Keywords: 3‑(4.5‑dimethylthiazol‑2yl)‑2.5‑diphenyltetrazolium bromide assay; Alpinia officinarum; amphotericin B; antileishmanial; Rosa damascene; Silybum marianum
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