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PM · Lens · The Role of the Herbal Medicines, Rehmanniae Radix, Citrus unshiu Peel, and Poria cocos Wolf, in High‑Fat Diet‑Induced Obesity

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Article · Volume 15, Issue 63 · pp. 363–368

The Role of the Herbal Medicines, Rehmanniae Radix, Citrus unshiu Peel, and Poria cocos Wolf, in High‑Fat Diet‑Induced Obesity

Min Ji Kwon1, Jung Nam Kim1, Eun Yeong Lim2,3, Yun Tai Kim2,3, Hyungwoo Kim4, Myeong Ho Jung1, Byung Joo Kim1

  1. 1Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University.
  2. 2Research Group of Innovative Special Food, Korea Food Research Institute, Wanju‑Gun.
  3. 3Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Republic of Korea.
  4. 4Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan.

Abstract

Objective: To investigate on the anti‑obesity effects of herbal medicines such as Rehmanniae radix (RR), Citrus unshiu peel (CUP), and Poria cocos wolf (PCW) in high‑fat diet (HFD)‑induced obese mice.Materials and Methods: C57BL/6 mice were fed a normal diet (ND) or an HFD for 6 weeks, and herbal medicines were administered orally three times a week for 8 weeks. Serum biochemical parameters were detected by measuring glucose, triglycerides, and total cholesterol. In addition, histological changes were observed in epididymal adipose tissues.Results: The RR, CUP, and PCW effectively lowered both the body weight and epididymal adipose tissue weight and reduced the adipocyte enlargement. In addition, we examined the serum biochemical profiles of HFD‑induced obese mice to confirm the anti‑obesity effects of RR, CUP, and PCW. Compared to the ND mice, the administration of RR, CUP, and PCW efficiently reduced the glucose, triglyceride, and total cholesterol serum levels in HFD‑induced obese mice.Conclusion: These findings suggested that the herbal medicines, such as RR, CUP, and PCW, are potential novel agents for the prevention and treatment of metabolic diseases, especially obesity.

Keywords: Citrus unshiu peel; high‑fat diet; obesity; Poria cocos wolf; Rehmanniae radix

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