Article · Volume 15, Issue 64S · pp. S320–S327

Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats

Anupama Sindhaghatta Kariyappa¹, Sowbhagya Ramachandregowda², Santosh Anand², Bhagyalakshmi Dundaiah¹

¹Mamatha Madhugiri Gopinath, Ravikiran Tekupalli Department of Biotechnology, Jnanabharathi Campus, Bangalore University, India.
²Ramaiah College of Arts Science and Commerce, Bengaluru, Karnataka, India.

Abstract

Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region‑specific responses against isoproterenol (ISO)‑induced myocardial injury in male Wistar rats.Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4‑hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days.Results: ISO‑treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO‑administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO‑induced myocardial infarction (MI).Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO‑induced MI in rats.

Keywords: Decalepis hamiltonii; isoproterenol; myocardial infarction; oxidative stress; serum lipid profile

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