Article · Volume 15, Issue 64S · pp. S359–S365
Catha edulis‑induced Skeletal Muscle Toxicity in Experimental Rats via Regulation of Rhabdomyolysis Biomarkers
Syam Mohan2, Emad Shaheen2, Yasmin O. El‑Amir3,4, Hussein A. Khadashi2, Saida S. Ncibi5, Abdullah Farasani2,6, Siddig Ibrahim Abdelwahab7
- 1Medical Research Centre, Jazan University.
- 2Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
- 3Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University.
- 4Department of Biology, Faculty of Science, Jazan University.
- 5Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University.
- 6Substance Abuse Research Center, Jazan University, Jazan, Saudi Arabia.
Abstract
Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities.Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Crotalaria pallida</em> Aiton (MECP) leaves.Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-induced granuloma models. The analgesic activity was assessed using acetic acid-induced writhing and hot plate methods in mice.Results: MECP (200 and 400 mg/kg) showed significant (P < 0.01) anti-inflammatory activity in both acute and chronic models. In the analgesic models, MECP exhibited significant (P < 0.01) reduction in the number of writhes and increased the reaction time in the hot plate test.Conclusion: The results suggest that <em>C. pallida</em> possesses significant anti-inflammatory and analgesic activities, which may be attributed to the presence of phytochemicals like flavonoids and alkaloids.
Keywords: Catha edulis; khat; muscle weakness; myoglobin; rhabdomyolysis
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