Article · Volume 16, Issue 67 · pp. 21–26
Dietary Supplementation of Hemidesmus indicus and Swimming Exercise Attenuates Oxidative Stress in the Rat Brain
Bhagyalakshmi Dundaiah1, Anupama Sindhaghatta Kariyappa1, Sowbhagya Ramachandregowda2, Santosh Anand1
- 1Ravikiran Tekupalli Department of Biotechnology, Bangalore University, India.
- 2Department of Biotechnology and Genetics, Ramaiah College of Arts Science and Commerce, Bengaluru, Karnataka, India.
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored.Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>.Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model.Results: The extract showed significant antioxidant activity in a dose-dependent manner. In the anti-inflammatory assay, the extract at 200 and 400 mg/kg doses significantly reduced paw edema compared to the control group.Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory activities, supporting its traditional use.
Keywords: Antioxidant enzymes; dietary supplementation; Hemidesmus indicus; oxidative stress; swimming exercise
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