Article · Volume 16, Issue 67 · pp. 51–56
Fucoxanthin Attenuates Behavior Deficits and Neuroinflammatory Response in 1‑Methyl‑4‑Phenyl‑1,2,3,6 ‑Tetrahydropyridine‑Induced Parkinson’s Disease in Mice
Guoqing Sun1, Tao Xin2, Rui Zhang2, Chengxiao Liu1, Qi Pang2
- 1Departments of Anesthesiology, Hospital Affiliated to Shandong University, Huaiyin District, Jinan, Shandong Province, PR China.
- 2Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Huaiyin District, Jinan, Shandong Province, PR, China.
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing.Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) in experimental animal models.Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, and analgesic activity was assessed using acetic acid-induced writhing and tail-flick methods in mice.Results: MECQ at doses of 200 and 400 mg/kg showed significant (P < 0.01) anti-inflammatory activity in carrageenan-induced rat paw edema. In analgesic models, MECQ exhibited significant (P < 0.01) reduction in the number of writhes in acetic acid-induced writhing test and increased the reaction time in tail-flick method.Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and analgesic activities, which supports its traditional use.
Keywords: Dopamine; fucoxanthin; inflammation; neuroprotective; Parkinson disease
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