Article · Volume 16, Issue 69 · pp. 250–257
Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway
Fang Luo1, Qing‑Chu Li1, Feng‑Jiao Zhang1, Lei Li1, Li‑Ge Song1, Yu Mao1, Jing Li1, Hong‑Mei Liu1, Feng‑Li Li1, Ling‑Yu Xu1
- 1Ya‑Jie Huo, Huan‑Huan Wang, Zhi‑Qiang Kang, Li He Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou City, Henan Province, China.
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored.Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>.Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model.Results: The extract showed significant antioxidant activity in a dose-dependent manner. In the anti-inflammatory assay, the extract at 200 and 400 mg/kg doses significantly reduced paw edema compared to the control group.Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory properties, supporting its traditional use.
Keywords: Adropin; antioxidant; nuclear factor erythroid 2‑related factor 2 pathway; obesity; proinflammatory cytokines
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