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PM · Lens · Effects of the Japanese Kampo Medicine, Rikkunshito, on Gastrointestinal Motility Functions

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Article · Volume 16, Issue 69 · pp. 343–346

Effects of the Japanese Kampo Medicine, Rikkunshito, on Gastrointestinal Motility Functions

Minwoo Hwang1, Donghun Han2, Byung Joo Kim2

  1. 1Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul.
  2. 2Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan, Korea.

Abstract

Objectives: The objective was to find the effect of GI motility with Rikkunshito.Materials and Methods: The prokinetic effect of Rikkunshito was investigated by studying the gastric emptying (GE) and intestinal transit rate (ITR) or experimentally induced GI motility dysfunction (GMD).Results: The oral administration of Rikkunshito significantly increased GE and ITR and restored the delayed GE and ITR. Its effect was similar to that of conventional prokinetics, such as domperidone and mosapride. Moreover, we made the mouse GMD models, such as acetic acid or streptozotocin, and ITR had shown a great decrease. This decrease was recovered by Rikkunshito.Conclusion: Rikkunshito revealed its prokinetic effect through an increase of GE and ITR. We found a great possibility of Rikkunshito for the GI control drug.

Keywords: Gastric emptying; gastrointestinal disease; intestinal transit rate; motility; rikkunshito

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