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PM · Lens · Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β‑Hexosaminidase in in-vitro Model of IgE‑Mediated Mast Cell Degranulation

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Article · Volume 16, Issue 69 · pp. 400–408

Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β‑Hexosaminidase in in-vitro Model of IgE‑Mediated Mast Cell Degranulation

Audrey Siew Foong Kow2, Lai Yen Fong2, Leng Wei Khoo3, Ji Wei Tan2, Ming-Tatt Lee4,5,6, Daud Ahmad Israf2, Faridah Abas3,7, Khozirah Shaari7,8, Chau Ling Tham2

  1. 1Department of Biomedical Science, Faculty of Medicine and Health Sciences.
  2. 2Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia.
  3. 3Faculty of Pharmaceutical Sciences, UCSI University, 56000 Kuala Lumpur, Malaysia.
  4. 4Graduate Institute of Brain and Mind Sciences, College of Medicine.
  5. 5Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
  6. 6Laboratory of Natural Products, Institute of Bioscience.
  7. 7Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia.

Abstract

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities.Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Crotalaria pallida</em> (MECP) whole plant.Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-induced granuloma models. The analgesic activity was assessed using acetic acid-induced writhing and tail-flick models in mice.Results: MECP (200 and 400 mg/kg) showed significant (P < 0.01) anti-inflammatory activity in both acute and chronic models. In the analgesic models, MECP exhibited significant (P < 0.01) reduction in the number of writhes and increased the reaction time in the tail-flick test.Conclusion: The results suggest that MECP possesses significant anti-inflammatory and analgesic activities, which may be attributed to the presence of phytochemicals like flavonoids and alkaloids.

Keywords: Clinacanthus nutans; histamine; IgE‑mediated mast cell degranulation; pro‑inflammatory mediators; β‑hexosaminidase

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