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PM · Lens · In vitro Antioxidant and Anti-inflammatory Activities of the Methanolic Extract of the Leaves of Cissus quadrangularis L.

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Article · Volume 16, Issue 70S · pp. S272–S275

In vitro Antioxidant and Anti-inflammatory Activities of the Methanolic Extract of the Leaves of Cissus quadrangularis L.

Fernando Calzada1, Miguel Valdés1, Elizabeth Barbosa2, Claudia Velázquez3, Elihú Bautista4

  1. 1Unidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades‑2° Piso CORCE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social.
  2. 2Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luís y Díaz Mirón, Cd México, 2Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo.
  3. 3CONACyT‑CIIDZA y División de Biología Molecular, Instituto Potosino de Investigación Cientifica y Tecnológica A. C., Camino a la Presa San José 2055, 78216 San Luis Potosí, México Submitted: 16‑Dec‑2019 Revised: 05‑Feb‑2020 Accepted: 27‑May‑2020 Published: 28‑Aug‑2020.

Abstract

Objectives: The present study was undertaken to evaluate a possible antipropulsive activity of the dichloromethane crude extract and two sesquiterpene lactones from Decachaeta incompta.Materials and Methods: Charcoal‑gum acacia, lactose and castor oil‑induced hyperperistalsis assays were used to assess the antipropulsive activity of the crude extract from D. incompta and its sesquiterpene lactones, incomptines A and B.Results: The antipropulsive activity of D. incompta was investigated by studying the effect of the aerial parts dichloromethane extract and incomptines in three models of induced hyperperistalsis in rats. Dichloromethane extract showed significant inhibition of charcoal‑gum acacia and castor oil‑induced hyperperistalsis with values of ID50 31.70 and 27.31 mg/kg, respectively. Incomptine A, showed significant inhibition of charcoal‑gum acacia, lactose and castor oil induced hyperperistalsis with values of ID50 21.10, 14.20 and 16.20 mmol/kg, respectively. In contrast, incomptine B showed inhibition of charcoal‑gum acacia and lactose‑induced hyperperistalsis with values of ID50 11.90 and 9.60 mmol/kg, respectively.Conclusion: The results indicate that dichloromethane extract of D. incompta and its sesquiterpene lactones have antipropulsive activity. Furthermore, these results give additional support to the reports of the traditional use of D. incompta for the treatment of diarrhea.

Keywords: Antipropulsive activity; Decachaeta incompta; Diarrhea; incomptine A; sesquiterpene lactones

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