Article · Volume 16, Issue 70S · pp. S435–S442
Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice
Wasim Raja2,3, Sonam Pandey2,4
- 1Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, 2 Department of Central Laboratory Facility, Central Laboratory Facility, Chhattisgarh Council of Science and Technology, Raipur, Chhattisgarh, 3 Gujarat State Biotechnology Mission, Gandhinagar, Gujarat, India ORIGINAL ARTICLE.
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored.Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>.Materials and Methods: The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and total antioxidant capacity assays. The anti-inflammatory activity was evaluated using the protein denaturation inhibition assay and the membrane stabilization assay.Results: The methanolic extract of <em>C. arnottiana</em> showed significant antioxidant activity in all the assays. It also exhibited potent anti-inflammatory activity by inhibiting protein denaturation and stabilizing the red blood cell membrane.Conclusion: The results suggest that <em>C. arnottiana</em> has significant antioxidant and anti-inflammatory potential, which could be attributed to the presence of phytochemicals like flavonoids and phenolic compounds.
Keywords: B16F10 cell line; chemoprevention; Lawsonia inermis; mehndi/henna; melanomas
The full text of this article is available as a PDF. Open the PDF.