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PM · Lens · Protective Effect of Caffeic Acid Phenethyl Ester against Acute and Subchronic Mice Cardiotoxicity Induced by Cyclophosphamide Alone or Plus Naproxen

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Article · Volume 16, Issue 71 · pp. 585–591

Protective Effect of Caffeic Acid Phenethyl Ester against Acute and Subchronic Mice Cardiotoxicity Induced by Cyclophosphamide Alone or Plus Naproxen

Promise Madu Emeka2, Mohamed A. Morsy2,3, Ibrahim A. Alhaider2,4, Muhammad S. Chohan5

  1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa, Saudi Arabia.
  2. 2Department of Pharmacology, Faculty of Medicine, Minia University, El‑Minia, Egypt.
  3. 3Departmen of R & D, Saudi Food and Drug Authority, Riyadh.
  4. 4Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa, Saudi Arabia.

Abstract

Objectives: This study aims to investigate the possible protective effect of caffeic acid phenethyl ester (CAPE) in the co‑administration of CYP and naproxen (NAP) with acute and subchronic treatments in mice.Materials and Methods: Male BALB/c mice were divided into two phases of acute (24 h) and subchronic (30 days) treatments, of which seven groups each were used. Two groups from both acute and subchronic treatments represented untreated controls and CAPE groups, while others were CYP, NAP, CYP+NAP, CYP+CAPE and CYP+NAP+CAPE groups for both treatments. The activity of the cardiac antioxidative enzyme catalase was measured. The levels of cardiac reduced glutathione (GSH), protein carbonyl and malondialdehyde (MDA) were also assayed. In addition, histopathology of the heart tissues and immunohistochemistry of endothelial nitric oxide synthase (eNOS) expression were evaluated.Results: Our results showed that catalase and GSH were significantly decreased in all subchronic treatments. Furthermore, protein carbonyl and MDA were increased in both acute and subchronic treatments. Histopathological examination showed hypertrophic cells induced by CYP, NAP, and in combination. Moreover, CYP, NAP and in combination, significantly reduced eNOS levels. However, CAPE significantly prevented changes induced by CYP and NAP in both treatment groups.Conclusion: These observations highlight the protective potentials of CAPE in CYP‑NAP‑induced cardiotoxicity.

Keywords: Caffeic acid phenethyl ester; cardiotoxicity; cyclophosphamide; naproxen; oxidative stress

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