Article · Volume 16, Issue 72 · pp. 730–732
Isolation of New Diterpene from Methanolic Extract of Capsicum annuum Linn. Fruits
Neeraj Kumar Fuloria1, Shivkanya Fuloria1, Vijay Kumar Sharma2, Mohammed Ali3, Amit Singh4, Pradeep Kumar Sharma2
- 1Faculty of Pharmacy, AIMST University, Bedong, Kedah, Malaysia.
- 2Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, Uttar Pradesh.
- 3School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi.
- 4Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Abstract
Objectives: The present investigation was intended to explore the CAFME for the presence of any new phytoisolate.Materials and Methods: The study involved the preparation of CAFME, followed by critical isolation through normal phase silica‑gel based column chromatography using various combinations of petroleum ether and chloroform. The phytoisolate was characterized using ultraviolet, Fourier transformed infrared, Nuclear magnetic resonance (1H, 13C, Distortion less enhancement by polarization transfer and correlation spectroscopy), and mass spectrometry.Results: The chromatographic critical isolation and spectrometric experiment over CAFME offered a new phytoisolate characterized as 3,11,15‑trimethyl‑14 β‑hydroxy‑n‑hexadeca‑7‑en‑4,18‑ol ide (CA‑1).Conclusion: The present study concludes the isolation of a new diterpene 3,11,15‑trimethyl‑14 β‑hydroxy‑n‑hexadeca‑7‑en‑4,18‑olide (CA‑1) for the first time in CAFME. The present study also recommends that in future this new phytoisolate should be further standardized and explored for its therapeutic properties.
Keywords: Capsicum; characterization; chromatography; diterpene; phytoisolate
The full text of this article is available as a PDF. Open the PDF.