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PM · Lens · Naringin, a Natural Flavonone Glycoside attenuates N-Nitrosodiethylamine- induced Hepatocellular Carcinoma in Sprague-Dawley rats

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Article · Volume 17, Issue 6S · pp. S196–S204

Naringin, a Natural Flavonone Glycoside attenuates N-Nitrosodiethylamine- induced Hepatocellular Carcinoma in Sprague-Dawley rats

Reetuparna Acharya1, Namita Mishra1, Abhishek Kumar1, Pritha Bose1, Ashok Pattnaik1, Kunal Mukhopadhyay2, Priyashree Sunita3, Shakti Prasad Pattanayak4

  1. 1Department of Pharmaceutical Sciences and Technology, Division of Pharmacology, Birla Institute of Technology, Ranchi, Jharkhand, India.
  2. 2Department of Biotechnology, Birla Institute of Technology, Ranchi, Jharkhand, India.
  3. 3Department of Health, Family Welfare and Medical Education, Government Pharmacy Institute, Government of Jharkhand, Ranchi, Jharkhand, India.
  4. 4Department of Pharmacy, School of Health Sciences, Central University of South Bihar, Government of India, Gaya, Bihar, India.

Abstract

Objectives: The present research work focuses on evaluation of chemotherapeutic efficiency, NAR against HCC in Sprague– Dawley rats.Materials and Methods: In vitro studies were primarily carried out to estimate the cell viability of NAR in HepG2 cells followed by further justifications through in vivo studies in N‑nitrosodiethylamine developed HCC. The efficacy of NAR at doses 30mg/kg/day and 60mg/kg/ day was assessed through estimation of liver marker enzymes, antioxidant levels, glycoproteins, and level of MMP‑2 and 9 to confirm the hypothesis.Results: While in vitro results revealed pronounced potency of NAR in inhibiting HepG2 cell viability, NAR concurrently stabilized the serum levels of liver marker enzymes, antioxidant levels, and serum glycoproteins. It also significantly reduced the levels of MMPs in treatment groups which was confirmed by zymography.Conclusion: With the support of these results, it can be concluded that NAR attenuates HCC by controlling the alterations in morphological, biochemical, and histopathological parameters that make it a suitable candidate as a potential chemotherapeutic agent against HCC.

Keywords: Hepatocellular carcinoma; matrix metalloproteinases; Naringin; N‑nitrosodiethylamine; zymography

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