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PM · Lens · Evaluation of Antioxidant and Anti-inflammatory Activities of Selected Cissus Species

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Article · Volume 17, Issue 73 · pp. 120–126

Evaluation of Antioxidant and Anti-inflammatory Activities of Selected Cissus Species

Preeti Rawat1, Pinki Rawat2, Piyush Kumar3, Sabita Kumari4, Anil Kumar1, Mahesh Pal1

  1. 1Phytochemistry Division, CSIR‑National Botanical Research Institute, Lucknow.
  2. 2Department of Pharmacy, Maharana Pratap College of Pharmacy, Kanpur.
  3. 3Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh.
  4. 4Department of Pharmaceutical Sciences and Technology, BIT, Ranchi, Jharkhand, Institute, Lucknow, India.

Abstract

Objectives: The present work was aimed at investigating the phytochemicals of methanolic extract of L. procumbens leaves and its isolated mixtures from column fractions.Materials and Methods: The method was successfully developed and two new compounds (chlorogenic acid and 7‑hydroxyflavanone) by liquid chromatography (LC)‑electrospray ionization (ESI)‑MS/MS and four new compounds (lactucin, isorhametin, 1‑monopalmitin, and 1‑hexacosanol) by ultra‑performance liquid chromatography (UPLC)‑ESI‑quad time of flight (QTOF)/MS in L. procumbens were identified. Identification of compounds by LC‑ESI‑MS/ MS and UPLC‑ESI‑QTOF/MS was identified based on the accurate mass of pseudomolecular [M+H]+ ion tandem mass spectrometry (MS/MS) data and by comparing retention times, mass spectra, and molecular weights with those published in the literature.Results: The six new compounds, namely chlorogenic acid, 7‑hydroxyflavanone, lactucin, isorhametin, 1‑monopalmitin, and 1‑hexacosanol were identified by in L. procumbens.Conclusion: A total of 26 compounds by gas chromatography‑MS and five compounds by LC mass‑ESI tandem mass spectrometry (LC‑ESI‑MS/ MS) and seven compounds by UPLC‑ESI tandem mass spectrometry/ quadrupole‑time‑of‑flight‑mass spectrometry (UPLC‑ESI‑QTOF/MS) technique were identified.

Keywords: Flavonoid; gas chromatography‑MS; Launaea; liquid chromatography‑electrospray ionization‑MS/MS; phenolic; ultra‑performance liquid chromatography‑electrospray ionization‑quad time of flight/MS

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