Article · Volume 17, Issue 76 · pp. 679–683
Antifibrotic Effects of Lilii Bulbus Extract in a Mouse Model of Bleomycin‑induced Pulmonary Fibrosis
Shuen‑Cheng Chiang1, Jihye Park2, Jinhyun Bae2, Hyejin Joo2,3, Donghyun Lee1, Kwan‑Il Kim1, Seok‑Jae Ko1, Jae‑Woo Park1, Youngmin Bu2, Beom‑Joon Lee1
- 1Department of Internal Medicine, College of Korean Medicine, Kyung Hee University.
- 2Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University.
- 3Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Dongdaemun‑gu, Seoul, Republic of Korea.
Abstract
Objectives: Lilii Bulbus (LB), a lung‑moistening herbal medicine, has been used to treat the symptoms of pulmonary fibrosis, including dry cough and dyspnea. In this study, we investigated whether LB water extract (LIB) has antifibrotic effects in a mouse model of bleomycin‑induced pulmonary fibrosis.Materials and Methods: The effects of LIB and its mechanisms of action were investigated in a mouse model of bleomycin‑induced (2 mg/kg, intratracheal) pulmonary fibrosis. LIB (30, 100, and 300 mg/kg) was administered orally twice daily for 10 days after induction. Changes in body weight, lung histology, inflammatory cells in bronchoalveolar lavage fluid (BALF), and the levels of transforming growth factor (TGF)‑β, α‑smooth muscle actin (α‑SMA), and proinflammatory cytokines were evaluated.Results: LIB treatment decreased histological fibrotic change according to Ashcroft score, inflammatory cells, including total cells, macrophages, inflammatory cytokines (tumor necrosis factor‑α and interleukin‑6) in BALF, and TGF‑β and α‑SMA production in lung tissue.Conclusion: LIB exerted antifibrotic effects in a mouse model of bleomycin‑induced pulmonary fibrosis by inhibiting inflammatory reactions and fibrotic mediators including TGF‑β and α‑SMA.
Keywords: Bleomycin; herbal medicine; Lilii Bulbus; pulmonary fibrosis; transforming growth factor‑β
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