Arbortristoside‑A: A Promising Bioactive Moiety from Nyctanthes arbortristis Linn. against Hemorrhoid

Abstract

Background: Hemorrhoid disease is becoming a common problem in modernized society and its treatment is less developed. Although there are many plants used traditionally, proper scientific evidence is still lacking. Nyctanthes arbortristis Linn. is scientifically proved to have pharmacological activities. In this research work, an approach has been made to establish the potentiality of arbortristoside‑A from N. arbortristis L. seeds against hemorrhoid.Materials and Methods: After characterization of arbortristoside‑A from N. arbortristis L seeds, it was subjected to explore its effectiveness against hemorrhoid using rat ileum and following croton oil‑induced hemorrhoid screening models.Results: Arbortristoside‑A observed to have a significant reduction in inflammation due to hemorrhoid at 50 and 100 mg/kg (1.25 ± 0.06 and 0.76 ± 0.05, respectively). Reduction of severity scores was observed in animals due to arbortristoside‑A mainly at its higher dose 100 mg/kg. It was also found to decrease the rectoanal coefficient significantly.Conclusion: Oral administration of arbortristoside‑A was proved to have significant anti-hemorrhoid effect which was well compared to that of the standard drug. In the course of time, this research work will be helpful in providing new entities to the field of medicines and pharmaceutical sciences for the treatment of hemorrhoid.

Keywords: Anti-hemorrhoid; arbortristoside‑A; hemorrhoid; in vitro; in vivo; Nyctanthes arbortristis