Article · Volume 17, Issue 76 · pp. 700–707
Antioxidant and anti-inflammatory activities of Cissus arnottiana B. Heyne ex Planch
Hui Yang1, Shanshan Yuan2, Yongsheng Li3
- 1Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), China.
- 2Departement of Gastroenterology, The Affiliated Xi’an Central Hospital of Xi’an Jiaotong University, China.
- 3Department of Pharmacy, Honghui Hospital, Xi’an Jiaotong University, Xi’an, China.
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored.Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em> B. Heyne ex Planch.Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the protein denaturation inhibition assay and the carrageenan-induced rat paw edema model.Results: The extract showed significant antioxidant activity in a concentration-dependent manner. In the anti-inflammatory assay, the extract exhibited significant inhibition of protein denaturation and reduced paw edema in rats compared to the standard drug, diclofenac sodium.Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory activities, supporting its traditional use.
Keywords: Claudin‑1; D‑pinitol; trinitrobenzene sulfonic acid; ulcerative colitis; zonu
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