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PM · Lens · Terfezia claveryi Chatin: Anti‑Tumor Effects against Ehrlich Solid Tumor in Mice

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Article · Volume 18, Issue 79 · pp. 651–658

Terfezia claveryi Chatin: Anti‑Tumor Effects against Ehrlich Solid Tumor in Mice

Norah A. Althobaiti1, Reem Hasaballah Alhasani2, Mona N. BinMowyna3, Aishah E Albalawi4, Ifat Alshari5

  1. 1Department of Biology, College of Science and Humanities-Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia.
  2. 2Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
  3. 3College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia.
  4. 4Faculty of Science, Department of Biology, University of Tabuk, Tabuk 47913, Saudi Arabia.
  5. 5Department of Biology, Jamoum University College, Umm Al-Qura University, Makkah, Saudi Arabia.

Abstract

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities.Objective: This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic activities of <em>Crotalaria pallida</em> Aiton.Materials and Methods: The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Anti-inflammatory activity was evaluated by the inhibition of protein denaturation and membrane stabilization assays. Cytotoxicity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against human breast cancer (MCF-7) cell lines.Results: The methanolic extract of <em>C. pallida</em> showed significant antioxidant activity with IC50 values of 42.15 ± 1.24 μg/mL for DPPH and 68.42 ± 2.15 μg/mL for FRAP. The extract also exhibited potent anti-inflammatory activity in a dose-dependent manner. In the MTT assay, the extract demonstrated significant cytotoxic activity against MCF-7 cells with an IC50 value of 56.32 ± 2.45 μg/mL.Conclusion: The results suggest that <em>C. pallida</em> possesses significant antioxidant, anti-inflammatory, and cytotoxic properties, which could be attributed to the presence of bioactive phytochemicals.

Keywords: Anticancer; cancer; herbal medicines; natural product; truffle

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