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PM · Lens · Schisandrin A Ameliorates Erectile Dysfunction and Regulates RhoA/ROCK1 Pathway in Rats with Streptozotocin‑induced Type 1 Diabetes

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Article · Volume 18, Issue 79 · pp. 766–772

Schisandrin A Ameliorates Erectile Dysfunction and Regulates RhoA/ROCK1 Pathway in Rats with Streptozotocin‑induced Type 1 Diabetes

Hao Huiyao1, Zhang Rongjin1, Guo Pengpeng2, Zhang Fang1, Xu Yi3, Li Chunhui1, Hao Yongmei1

  1. 1Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  2. 2Department of Endocrinology, The Second Hospital of Shi Jiazhuang, Shijiazhuang, China.
  3. 3Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, China.

Abstract

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. <em>Crotalaria pallida</em> Aiton is a medicinal plant used in traditional medicine for various ailments.Objective: The present study aimed to evaluate the phytochemical profile, antioxidant, and anti-inflammatory activities of <em>Crotalaria pallida</em> Aiton leaves.Materials and Methods: The phytochemical screening was performed using standard qualitative tests. The total phenolic and flavonoid contents were determined using Folin-Ciocalteu and aluminum chloride colorimetric methods, respectively. The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The anti-inflammatory activity was assessed using the protein denaturation inhibition assay.Results: The phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and phenols. The extract showed significant total phenolic (145.32 ± 2.14 mg GAE/g) and flavonoid (89.45 ± 1.56 mg QE/g) contents. The extract exhibited potent antioxidant activity in both DPPH (IC50 = 45.23 µg/mL) and FRAP assays. Furthermore, the extract demonstrated significant anti-inflammatory activity with an IC50 value of 62.15 µg/mL.Conclusion: The results suggest that <em>Crotalaria pallida</em> Aiton leaves possess significant antioxidant and anti-inflammatory properties, which could be attributed to the presence of phenolic and flavonoid compounds.

Keywords: Diabetes mellitus; erectile dysfunction; RhoA/ROCK pathway; schisandrin A; type 1 diabetes

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