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Pharmacognosy MagazineNOW IN
Article

Apoptosis‑Mediated Anticancer Activity of Geraniol Inhibits NF‑κB, MAPK, and JAK‑STAT‑3 Signaling Pathways in Human Thyroid Cancer Cells

1★, 1★, 2, 1★★ Corresponding author

  1. 1Department of Head and Neck Surgery, Hospital of Hebei University, Baoding, China.
  2. 2Administration Office of Medical Record, Affiliated Hospital of Hebei University, Baoding, China.

CORRESPONDENCE

Hongli Yang

Department of Head and Neck Surgery, Hospital of Hebei University, Baoding, China.

xishuai761011@sina.com

Received: 20-05-2021; Revised: 16-11-2021; Accepted: 01-08-2022.

Volume 18, Issue 80 · pp. 1183–1189 · 2022 · DOI: 10.4103/pm.pm_223_21

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ABSTRACT

Aim: Thyroid cancer accounts for 3.8% of the total endocrine cancer and is the fifth most diagnosed cancer among Indian women. Geraniol possesses pharmacological properties, including anti‑inflammatory, anti‑cancer, and neuroprotective properties. The anti‑cancer activity of geraniol on TPC‑1 cells was assessed in this study.Materials and Methods: The anticancer activity of geraniol in TPC‑1 cells was evaluated by MTT test, ROS, DAPI, PI, and AO/EB staining. mRNA and expression were assessed by qPCR and western blot.Results: The geraniol has shown cytotoxic effects toward TPC‑1 cells and showed an IC50 value of 25 µM, which decreases cell viability and inhibited cell proliferation. It also increased the accumulation of intracellular ROS, which induces apoptosis in the TPC‑1 cells due to the dissipation of membrane potential and disruption of mitochondria. There is a substantial reduction in the mRNA level expressions of Bcl‑2, Cyclin D1, c‑Myc, COX‑2, TNF‑α, NF‑κB, IL‑6, and surviving. It also upregulated the Bax and caspase‑3 mRNA expression suggesting cell death‑mediated apoptosis.Conclusion: We report that geraniol effectively inhibited the JAK‑2, STAT‑3, and ERK signaling pathways depicting geraniol as a potential therapeutic molecule for thyroid cancer treatment.

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    Yang, H., Zhang, Y., Cui, J., & Hao, Z. (2022). Apoptosis‑Mediated Anticancer Activity of Geraniol Inhibits NF‑κB, MAPK, and JAK‑STAT‑3 Signaling Pathways in Human Thyroid Cancer Cells. Pharmacognosy Magazine, 18(80), 1183–1189. https://doi.org/10.4103/pm.pm_223_21