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PM · Lens · Green Synthesis‑Mediated Iron Oxide Nanoparticles using Sphagneticola trilobata (L.) for Antibacterial and Anticancer Assessment

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Article · Volume 18, Issue 80 · pp. 953–961

Green Synthesis‑Mediated Iron Oxide Nanoparticles using Sphagneticola trilobata (L.) for Antibacterial and Anticancer Assessment

Rakesh Pandit Dhavale1, Swapnil Sanjay Patil2, Sagar Ujwal Jadhav3, Rushikesh Pandit Dhavale4, Sachin Bharat Agawane5

  1. 1Departments of Pharmaceutics, College of Pharmacy, Kolhapur, South Korea.
  2. 2Pharmaceutical Quality Assurance and, South Korea.
  3. 3Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, South Korea.
  4. 4Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
  5. 5Division of Biochemical Science, National Chemical Laboratory, Pune, Maharashtra, India.

Abstract

Objectives: The synthesis of Fe‑NPs using Sphagneticola trilobata leaf extract using ferric chloride solution and its biological assessment.Materials and Methods: The present study involved the synthesis of Fe‑NPs using S. trilobata leaf extract using ferric chloride solution by the co‑precipitation method. The synthesized nanoparticles were characterized for Fourier‑transform infrared spectroscopy, scanning electron microscopy, powder X‑ray diffraction spectroscopy, particle size analysis, and magnetization studies. The nanoparticles were biologically evaluated for microbiological, antioxidant, and in vitro cytotoxicity activity.Results: Magnetic nanoparticles were appeared in dark brown color. The change in color might result due to the presence of polyphenols in S. trilobata leaf extract. The characterization studies confirmed morphology, shape, and size of the nanoparticles. The mean diameter of Fe‑NPs and S. trilobata‑Fe‑NPs was found to be 42.2 ± 2.6 and 62.54 ± 2.01 nm, respectively. Magnetization studies of nanoparticles revealed ferromagnetic behavior with the saturation magnetization at 57 emugm−1. S. trilobata‑Fe‑NPs showed significant antibacterial action against Staphylococcus aureus and Bacillus subtilis by the well‑diffusion method. Antioxidant activity of S. trilobata‑Fe‑NPs exhibited 65.78% inhibition in comparison with ascorbic acid. The cytotoxicity assay of S. trilobata‑Fe‑NPs on HCT‑15 colon adenocarcinoma cells showed significant anticancer activity (56.44%) cytotoxic inhibition.Conclusion: Green synthesis‑mediated S. trilobata‑Fe‑NPs appeared to produce significant antimicrobial and anticancer potential.

Keywords: Elemental analysis; field emission scanning electron microscopy; green synthesis; iron oxide nanoparticles; Sphagneticola trilobata; X‑ray diffraction

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