Article · Volume 19, Issue 1 · pp. 49–55
Jasminum elongatum Ameliorates Acetaminophen Induced Hepatotoxicity by Modulating Dysregulated Antioxidant Enzyme System
Sabeena Hussain Syed1, Supriya Unavane1, Poonam Taru1, Bindurani L. G. P. Ram1, Sachin Shridhar Sakat1, Sonali Manwatkar1, Ajay Gajanan Namdeo2
- 1School of Pharmacy, Vishwakarma University, Kondhwa, Pune, Maharashtra 411048, INDIA.
- 2Poona College of Pharmacy, Bharati Vidyapeeth (Deemed University), Kothrud, Pune, Maharashtra, INDIA.
Abstract
Objectives: To evaluate the hepatoprotective activity of fractions of Jasminum elongatum methanolic extract against acetaminophen-induced hepatic damage.Materials and Methods: Fractions obtained from methanolic extract of J. elongatum (petroleum ether, chloroform and hydroalcoholic) were investigated for hepatoprotective activity. Doses of 100 mg/kg and 200 mg/kg of different fractions were administered for 7 days, and acetaminophen toxicity was induced on the eighth day. After 24 hr of toxicity induction, biochemical markers and histological alterations were measured to determine the amount of hepatoprotection.Results: The chloroform and hydroalcoholic fractions showed a significant decrease in biochemical parameters when compared to the toxic group, which was confirmed by histopathological changes and antioxidant parameters.Conclusion: The results of this study revealed that the chloroform and hydroalcoholic fraction of J. elongatum have significant hepatoprotective activity against acetaminophen-induced toxicity.
Keywords: Jasminum elongatum; hepatoprotection; acetaminophen; antioxidant; biochemical parameters; histopathology
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