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PM · Lens · Deoxyschizandrin Inhibits PTEN to Regulate Inflammation in Doxorubicin-induced Hepatotoxicity

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Article · Volume 19, Issue 2 · pp. 439–447

Deoxyschizandrin Inhibits PTEN to Regulate Inflammation in Doxorubicin-induced Hepatotoxicity

Jinhai Wang1, Naijing Zhou2

  1. 1Department of Emergency, Affiliated Changzhou Municipal No. 2 People’s Hospital, Nanjing Medical University, Changzhou, PEOPLE’S REPUBLIC OF CHINA.
  2. 2Department of Critical Care Medicine, Affiliated Changzhou Municipal No. 2 People’s Hospital, Nanjing Medical University, Changzhou, PEOPLE’S REPUBLIC OF CHINA.

Abstract

Aim: Doxorubicin (DOX) has long been criticized for its cardiotoxicity, yet one cannot overlook its hepatotoxicity. Deoxyschizandrin (Deo) is a type of monomer used in traditional Chinese medicine that has a powerful anti-inflammatory action and is frequently used to treat a variety of inflammatory diseases. However, its therapeutic effect on DOX-induced hepatotoxic inflammatory reactions is still unknown.Materials and Methods: In this study, DOX was used to induce hepatotoxicity in rats, and the effects of Deo on hepatotoxicity and hepatic inflammation were investigated.Results: The results show that Deo protects liver function by inhibiting PETN, which regulates DOX-induced liver inflammation.Conclusion: The anti-inflammatory effect of Deo in DOX-induced hepatotoxicity is attributed to the inhibition of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and the increase in AKT phosphorylation.

Keywords: Deoxyschizandin; doxorubicin; hepatotoxicity; inflammation; PTEN

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