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PM · Lens · Phytochemical Profile, Antioxidant and Antiproliferative Activity from Leaves and Seeds of Bixa orellana L. from the Yucatán Peninsula, Mexico

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Article · Volume 19, Issue 2 · pp. 482–490

Phytochemical Profile, Antioxidant and Antiproliferative Activity from Leaves and Seeds of Bixa orellana L. from the Yucatán Peninsula, Mexico

Dora Valencia1, Dolores Isela Aguilar-González1, Jesús Ortega-García1, Gregorio Godoy-Hernández2, Mario Alberto Leyva-Peralta1, Víctor Manuel Moo-Huchín3, Rayn Clarenc Aarland4, Jael Quintero-Vargas5, José Alberto Mendoza-Espinoza6, Addy Leticia Zarza-García7

  1. 1Departamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, Ave. Universidad e Irigoyen, Sonora, México.
  2. 2Unidad de Bioquímica y Biología Molecular de Plantas. Centro de Investigación Científica de Yucatán. Calle 43 No. 130. Col. Chuburná de Hidalgo, Yucatán, México.
  3. 3División de Estudios de Posgrado e Investigación, Tecnológico Nacional de México, Instituto Tecnológico de Mérida, Yucatán, Mexico.
  4. 4Centro de Investigación en Biología Molecular Vegetal. Centro Universitario de la Ciénega. Universidad de Guadalajara, Ocotlán, Jalisco.
  5. 5Departamento de Ciencias de la Salud. Universidad de Sonora, Sonora, México.
  6. 6Colegio de Ciencias y Humanidades, Academia de Biología Humana, Universidad Autónoma de la Ciudad de México, México. On Sabbatical at the Department of Mechanical and Aerospace Engineering, University of California, San Diego from January to December 2022
  7. 7Facultad Ciencias de la Salud. Universidad Autónoma del Carmen. Ave. Central s/n esquina. Fracc. Mundo Maya, 24150. Cd. Carmen, Campeche, México.

Abstract

Background: In Mexico, there is an ancestral custom about the knowledge of the medicinal use of plants. Bixa orellana L. is a plant species that represents one of the main crops used in traditional medicine in southeastern Mexico. Background studies on its biological properties have been conducted on accessions harvested in Conkal, Yucatan, Mexico.Objectives: In this work, the idea was to perform a phytochemical analysis of methanolic extracts of B. orellana.Materials and Methods: Phytochemical screening was performed on methanolic extracts of leaves and seeds from two accessions of B. orellana, as well as on their antioxidant and antiproliferative activities.Results: The phytochemical screening of the methanolic extracts of the leaves revealed the presence of tannins, terpenes, and saponins. A higher total content of phenols and flavonoids in leaves was also found compared to seeds, which coincides with a higher antioxidant activity in leaves compared to seeds. Regarding antiproliferative activity, the seeds and leaves of accession 3 showed the best results.Conclusion: Accession 3 has better bioactive properties and can be a candidate in the search for antiproliferative and antioxidant compounds; this is the first study that associates this plant with this activity and demonstrates the chemical differences that exist between the accessions of B. orellana.

Keywords: Antioxidant activity; accessions; Bixa orellana L; antiproliferative activity

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