jrnls.org logo
Submit

BROWSE ALL JOURNALS

Type 2 letters to search all 19 journals

SEE ALL 19 JOURNALS
Pharmacognosy MagazineNOW IN
Back

PM · Lens · Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol

PDF

Article · Volume 2, Issue 5 · pp. 42–43

Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol

Sengottuvelan M1, Nalini N1

  1. 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.

Abstract

The purpose of the present study was to investigate the effect of resveratrol (RES) on 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. The numbers of colon tumors and the formation of aberrant crypt foci (ACF), a premalignant lesion in rats were significantly reduced on resveratrol (8 mg/kg body weight) supplementation. Moreover, resveratrol supplementation for the entire treatment period showed significantly better chemopreventive activity against DMH-induced rat colon carcinogenesis as compared to resveratrol supplementation during the initiation and post-initiation stages of carcinogenesis.

Keywords: Resveratrol; 1,2-Dimethylhydrazine; Aberrant crypt foci; Chemoprevention; Colon carcinogenesis

The full text of this article is available as a PDF. Open the PDF.