Protective Effect of Tefroli - a polyherbal mixture (Tonic) on cadmium chloride induced hepatotoxic rats

Abstract

Tefroli is a type of ayurvedic tonic composed of 6 herbal extract mixtures such as Phyllanthus niruri, Ocimum sanctum, Tephrosia purpurea, Andrographis paniculata, Eclipta alba and Terminalia chebula and the importance of the present work is to evaluate the protective effect of Tefroli tonic (a poly herbal mixture) against cadmium induced hepatotoxicity in experimental rats. Subcutaneous injection of cadmium chloride (CdCl2) to rats caused liver damage and was observed by analysis of serum bilirubin and assay of marker enzymes such as transaminases and phosphatases of both serum and liver. Histopathological observation of hepatic tissue also showed marked changes in liver cells. Oral administration of Tefroli to CdCl2 induced hepatotoxic rats reversed the above parameters to near normal levels. From this study, it is concluded that the administration of Tefroli tonic has maximum protective effect against cadmium-chloride induced hepatotoxicity in experimental rats.

Keywords: Cadmium chloride; Histopathology; Marker enzymes; Tefroli; Serum Bilirubin