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PM · Lens · Changes in the regional protein metabolism in the central nervous system (CNS) of diabetic rats: Protection by Cichorium intybus (Chicory)

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Communication · Volume 2, Issue 6 · pp. 130–132

Changes in the regional protein metabolism in the central nervous system (CNS) of diabetic rats: Protection by Cichorium intybus (Chicory)

Nayeemunnisa Nayeemunnisa1,2,3, Nawaz R1,2,3, Jayashree C1,2,3

  1. 1Dept. of Pharmacognosy, Al-Ameen College of Pharmacy, Bangalore, 560 027, India.
  2. 2Dept. of Zoology, Bangalore University, Bangalore 560 056, India.
  3. 3King Abdul Aziz hospital, Jeddah, Kingdom of Saudi Arabia.

Abstract

Protein content, ammonia and activity levels of Glutamate dehydrogenase (GDH) in the cerebrum, medulla oblongata of noarmal and alloxan – diabetic rats were measured. Protein content decreased in the regions of the brain studied during the diabetic state. Ammonia levels were also increased in the brain of alloxan diabetic rats. The activity level of glutamate dehydrogenase in the broad compartments of the brain was decreased during alloxan induced diabetes. Chicory offered marked protection, it brought down the levels of blood glucose and brain ammonia.

Keywords: Protein metabolism; CNS; Diabetes; Ammonia; GDH; Cichorium intybus; protection

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