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PM · Lens · Inhibition of nitric oxide and interferon-γ production by iridoids and triterpenes from the roots of Himatanthus sucuuba

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Article · Volume 2, Issue 8 · pp. 216–217

Inhibition of nitric oxide and interferon-γ production by iridoids and triterpenes from the roots of Himatanthus sucuuba

Marinete S. Souza1, Milade dos S. Cordeiro1, Elaine C. Rosas2, Maria das Graças O. M. Henriques2, Antonio C. Siani2

  1. 1Departamento de Química Orgânica, Instituto de Química, Fundação Universidade do Amazonas, Manaus, AM, Brazil.
  2. 2Laboratório de Química de Produtos Naturais e Farmacologia Aplicada, Far-Manguinhos, Fundação Oswaldo Cruz, Rua Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil.

Abstract

The iridoids β-dihydroplumericin (1), plumericin and isoplumericin were isolated from the roots of Himatanthus sucuuba, along with lupeol acetate and cinnamate. The isolated compounds and three different crude extracts from the roots exhibited in vitro immunoregulatory activity in the nitric oxide and interferon-γ inhibition assays, when tested below the cytotoxic concentrations.

Keywords: Himatanthus sucuuba; iridoid; triterpene; β-dihydroplumericin; immunoregulatory activity

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