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PM · Lens · Modulations by L-Carvone and Thymoquinone to Exert Protection on Bone Marrow Cells Against Benzene-induced Toxicities Through Anti-inflammatory Pathways in SD Rats

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Article · Volume 20, Issue 1 · pp. 280–290

Modulations by L-Carvone and Thymoquinone to Exert Protection on Bone Marrow Cells Against Benzene-induced Toxicities Through Anti-inflammatory Pathways in SD Rats

Enjun Kong1, Yan Xu2, Hong Jin3, Tahani Awad Alahmadi4, Samer Hasan Hussein Al Ali5

  1. 1Department of Chemistry, Faculty of Science, Isra University, Amman, JORDAN.
  2. 2Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, Riyadh, SAUDI ARABIA.
  3. 3The Second Department of Internal Medicine, Zibo Maternal and Child Health Hospital, Zibo, Shandong Province, CHINA.
  4. 4Department of Rheumatology and Hematology, The People’s Hospital of Danyang, Danyang, Jiangsu Province, CHINA.
  5. 5Department of Emergency Medicine, The People’s Hospital of Danyang, Danyang, Jiangsu Province, China.

Abstract

Background: Adverse effects of benzene (BZ) exposure toxicities were documented by many researchers worldwide. BZ exposure causes many hematological abnormalities that might be treated with naturally occurring phytocompounds.Aim: In this experimental study, we evaluated the anti-inflammatory effect of L-carvone and thymoquinone together (LCTQ) against BZ-induced inflammatory toxicities in Sprague-Dawley (SD) rats.Introduction: BZ exposure could cause an excess formation of immature blood cells to enter the peripheral bloodstream. Phytocompounds namely L-carvone (LC) and thymoquinone (TQ) have confirmed anti-inflammatory effects against various diseases.Materials and Methods: Rats were divided into four different groups such as control, LCTQ group, BZ pathologic group, and treatment group (LCTQ+BZ). After 10 weeks of the experimental period, body weight changes, hematological parameters, pro-inflammatory cytokines, oxidative stress, RBC antioxidants, bone marrow cellular abnormalities, and bone marrow DNA fragmentation were evaluated.Results: BZ toxicity showed abnormal loss of body weight, altered hematological parameters, increased pro-inflammatory cytokines, abnormal cellular oxidative status, and DNA damage. LCTQ treatment showed significant (p < 0.05) increase in body weight, normalized hematological parameters such as red blood cells, hemoglobin, white blood cells (lymphocytes and eosinophils), platelets (PLT), and hematocrit with RBC parameters, reduction of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), controlled oxidative stress, normalized enzymatic antioxidants in the RBC cells, normalized nucleated cells, megakaryocyte cells, and controlled DNA fragmentation were observed.Conclusion: The current study showed an anti-inflammatory effect of LCTQ through the control of inflammation against benzene-induced toxicities in rats.

Keywords: L-Carvone; thymoquinone; benzene; cytokine; DNA fragmentation

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