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PM · Lens · Schisandrol A Relaxes the Rat Trachea Via L-Type Ca2+ Channels and KV Channels

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Article · Volume 20, Issue 4 · pp. 1237–1247

Schisandrol A Relaxes the Rat Trachea Via L-Type Ca2+ Channels and KV Channels

Zhiying Xu1, Chengcheng Lin2, Jinghui Sun2, He Li2, Wenyue Zhuang3, Jianguang Chen2, Chunmei Wang2, Haili Wang4

  1. 1Department of Pharmacy, Affiliated Hospital, Beihua University, Jilin City, Jilin Province, China
  2. 2Department of Pharmacology, School of Pharmacy, Beihua University, Jilin City, Jilin Province, China
  3. 3Department of Molecular Biology, School of Laboratory Medicine, Beihua University, Jilin City, Jilin Province, China
  4. 4Department of Hepatology, Affiliated Hospital, Beihua University, Jilin City, Jilin Province, China

Abstract

Background: Schisandra chinensis is widely applied in the prevention and treatment of asthma in China, but the material basis for the anti-asthmatic effect of S. chinensis is unclear. Our previous studies found that the lignans from S. chinensis can relax tracheal smooth muscle in rats. Schisandrol A (SCA) is a representative monomer of S. chinensis lignans with high content and activity.Purpose: This study was aimed at further exploring the relaxation effect of SCA and its mechanism on the isolated tracheal smooth muscle of rats through tracheal perfusion experiments.Materials and Methods: The isolated rat tracheal ring was precontracted with acetylcholine (ACh). Then, the impact of SCA on the tension of precontracted tracheal ring was studied. Verapamil (L-type calcium channel blocker) and four potassium channel blockers, including glibenclamide, tetraethylamine, 4-aminopyridine (4-AP), and barium chloride (BaCl2), as well as propranolol (β-adrenergic receptor antagonist), were respectively used to precontract the tracheal ring for investigation.Results: SCA could dose-dependently reduce the ACh-induced contraction of the tracheal ring, and the verapamil and 4-AP could weaken this effect, while BaCl2, glibenclamide, tetraethylamine, and propranolol did not show this effect.Conclusion: SCA can significantly relax the effect of tracheal smooth muscle of rats, and the underlying mechanism might be involved in the blocking of L-type Ca2+ channels and activating the voltage-dependent potassium channels (KV).

Keywords: Schisandrol A; tracheal smooth muscle; relaxation; calcium channel; voltage-dependent potassium channel

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