PhcogMag 21 3 1013

Abstract

Background: One significant consequence of sepsis and a major factor in death in critical care units is acute lung injury (ALI). Purpurin has been proven in studies to minimize oxidative stress and inflammation.Objectives: It is yet unknown, nevertheless, how lipopolysaccharide (LPS)-induced ALI is protected against by purpurin’s anti-inflammatory and antioxidative properties.Materials and Methods: Male Sprague-Dawley rats were administrated with an intraperitoneal injection of LPS (5 mg/kg) to create an ALI model. The animals were divided into four groups: the control animals (group I), LPS-treated control animals (group II), purpurin treated animals in a dose-based manner (groups III and IV).Results: The animals in group II exhibited increased levels of macrophages, neutrophils, lung injury, inflammatory cytokines, myeloperoxidase (MPO), nitric oxide (NO), reactive oxygen species (ROS), and endothelial cell permeability. The level of antioxidants was reduced in the group II animals. Purpurin treatment in a dose-based manner to the LPS-treated animals considerably reduced the level of macrophages, neutrophils, lung injury, inflammatory cytokines, MPO, NO, ROS, and endothelial cell permeability. In addition, it increases the antioxidant levels in the lung tissue.Conclusion: In summary, purpurin can ameliorate ALI induced by LPS through antioxidative and anti-inflammatory effects. Nursing care for patients with sepsis-related acute lung disease (ALD) requires monitoring vital signs, supportive care, supplemental oxygen therapy, ventilator settings, fluid balance, and pharmacological interventions like purpurin. Nutritional support, infection control, and collaboration with a multidisciplinary team are crucial.

Keywords: Acute lung injury; sepsis; inflammatory; purpurin; antioxidative