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PM · Lens · The Pharmacological Research of Traditional Chinese Medicine and Herbal Remedies in the Treatment of Melanoma

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Review · Volume 21, Issue 3 · pp. 738–750

The Pharmacological Research of Traditional Chinese Medicine and Herbal Remedies in the Treatment of Melanoma

Shuang Yan1,2,3, Yawei Wang4, Jing Zeng5, Dan Liu1, Haichuan Qin1, Chengzhen Du1, Qiao Xiang1, Li Yang3, Ling Li5, Yuxin He5

  1. 1Sichuan University of Arts and Science, Dazhou, Sichuan, CHINA.
  2. 2Key Laboratory of Exploitation and Study of Distinctive Plants in Education Department of Sichuan Province, Dazhou, Sichuan, CHINA.
  3. 3Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Zigong, Sichuan, CHINA.
  4. 4Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center, Nanjing, Jiangsu, CHINA.
  5. 5College of Food and Bioengineering, Xihua University, Chengdu, Sichuan, CHINA.

Abstract

Background: Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug resistance, toxic side effects, and recurrence.Objectives: This review aims to evaluate the therapeutic potential of natural products in the treatment of melanoma and to identify the associated challenges and future research opportunities.Methodology: A comprehensive literature search was conducted using PubMed and Web of Science to identify studies reporting on natural products with anti-melanoma activity.Results: Natural products demonstrate diverse pharmacological activities, including antiproliferative, proapoptotic, and antimetastatic effects, highlighting their potential in melanoma treatment. However, challenges such as limited efficacy, safety concerns, and the lack of standardized formulations remain significant barriers.Conclusion: This review provides insights into the therapeutic applications of natural products for melanoma, discusses existing limitations, and proposes future directions, contributing to the development of effective and safe anti-melanoma treatments.

Keywords: Melanoma; pathogenesis; traditional Chinese medicine; herbal medicine; antimelanin activity

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