Article · Volume 3, Issue 10 · pp. 101–102

Hypoglycemic and Anti-hyperglycemic Effect of Alcoholic Extract of Benincasa hispida in Normal and in Alloxan Induced Diabetic Rats

G. R. Battu¹, S. N. Mamidipalli¹, R. Parimi¹, R. K. Viriyala¹, R. P. Patchula¹, L. R. Mood¹

¹Pharmacognosy and Phytochemistry Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530 003, India.

Abstract

The hypoglycemic and anti-hyperglycemic effect of alcoholic extract of Benincasa hispida was investigated in normal and alloxan induced diabetic rats. A single oral administration of alcoholic extract of Benincasa hispida at doses 50,100,200mg/kg produced a significant blood glucose reduction in a dose dependent manner. A bioguided extraction and fractionation of alcoholic extract of the stem of Benincasa hispida afforded three compounds, β-sitosterol, α-amyrin, quercetin. The alcoholic extract at 200mg/kg significantly reduced the blood glucose levels and equipotent with that of the standard drug Tolbutamide.

Keywords: Diabetes mellitus; Benincasa hispida; Alloxan

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