Article · Volume 3, Issue 9 · pp. 34–35

Hematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem

M.T. Yakubu¹, M. A. Akanji¹, A. T. Oladiji¹

¹Medicinal Plant Research Laboratory, Department of Biochemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria.

Abstract

The haematological indices (Haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Mean Corpuscular Volume (MCV), Red Blood Cell Count (RBC), White Blood Cell Count (WBC), Platelets, Neutrophil and Eosinophil) following oral administration of aqueous extract of Fadogia agrestis stem at the doses of 18, 50 and 100mg/kg body weight in male albino rats were evaluated progressively on daily basis at 24hrs after 1, 7, 14 and 21days. Extract administration significantly altered (P<0.05) WBC count and those relating to it while it produced no significant change on RBC count and its related indices (P>0.05). The result suggest that aqueous extract of Fadogia agrestis stem has exhibited localized systemic toxicity which will impair the normal functioning of the WBC and its related indices.

Keywords: Fadogia agrestis; haematological indices; systemic toxicity

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