Article · Volume 4, Issue 13S · pp. 112–114
Analgesic effects of methanolic extract of Capparis zeylanica Linn. roots
A.B. Upaganlawar1, V.V. Chopade1, B.V. Ghule1, P.G. Yeole1
- 1Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha 442 001 (M.S.), India.
Abstract
The present study was aimed to investigate the analgesic effects of the methanolic extract of Capparis zeylanica Linn. (MECZ) roots in rats and mice. The MECZ (250- 500 mg/kg; p.o.) was evaluated for its analgesic activity by employing acetic acid-induced writhing test, hot plate test and tail immersion tests i.e. in hot and cold water. MECZ (250- 500 mg/kg; p.o.) showed significant (P<0.01) reduction in the number of writhing induced by acetic acid, increased reaction time in hot plate test and elevated pain threshold in hot and cold water tests. MECZ exhibited the dose-dependent analgesic effects. In addition, the acute toxicity studies revealed that MECZ has good margin of safety and did not show the lethal effects on the animals up to the doses of 4 g/kg.
Keywords: Capparis zeylanica; Analgesic activity; Writhing; Hot plate; Tail immersion tests
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