Article · Volume 4, Issue 15 · pp. 182–183

Preventive and curative effects of Vedic Guard against anti- tubercular drugs induced hepatic damage in rats

Rema Razdan¹, Imranulla Imranulla¹, Amar Dev M.J.¹

¹Dept. of Pharmacology, Al Ameen College of Pharmacy, Lalbagh road, Bangalore – 560027, India.
²Visveswarapura Institute of Pharmaceutical Sciences, Banashankari 2 nd stage, Bangalore – 560070, India.

Abstract

Vedic Guard, a polyherbal formulation in Ayurveda has been investigated for its possible or claimed hepatoprotective potential. Anti-tuberculosis drugs caused an increase in the activity of serum diagnostic markers ASAT, ALAT, ALP and total bilirubin, and a decrease in total plasma protein. Hepatic liver peroxidation was enhanced and free radical scavenging enzyme levels of superoxide dismuase (SOD), catalase (CAT) and glutathione (GSH) were reduced. Administration of Vedic Guard simultaneously with anti-TB drugs for 45 days prevented the alterations induced by the anti-TB drugs in the markers of liver function test and markers of oxidative stress. Treatment with Vedic Guard for 20 days post 45 days administration of anti TB drugs reversed the damage caused by the toxicant. Improvement in the histoarchitecture of liver also supported the biochemical studies. In conclusion, Vedic Guard exhibited preventive and curative effects on the hepatotoxicity induced by anti-TB drugs in rats.

Keywords: Vedic Guard; Hepatoprotective activity; Antioxidative activity

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