Anti-ulcer properties of 70% ethanolic extract of leaves of Albizzia lebbeck

Abstract

This study was designed to determine the gastro-protective effect of 70% ethanolic extract of leaves of Albizzia lebbeck in pylorus ligation, ethanol and indomethacin induced models in rat. The 70% ethanolic extract of leaves of Albizzia lebbeck was prepared and subjected to acute toxicity study as per CPCSEA guideline no. 420. Two doses i.e. 100 mg/kg and 200 mg/kg were selected for the further study. In pylorus ligation induced ulcer model, the parameters studied were gastric volume, pH, free acidity, total acidity and ulcer index. Ulcer index was also determined in ethanol and indomethacin induced ulcer models. Pretreatment with the extract (100mg/kg, 200 mg/kg) has shown dose dependant decrease in ulcer index in all the experimental models of ulcers (indomethacin, ethanol and pylorus ligation induced ulcers). The prior administration of extract (100 mg/kg and 200 mg/kg doses) also reduced the total acidity (58.50 and 46.17), free acidity (51.48 and 40.05) and increased the pH (2.58 and 5.15). However, the gastric volume was not reduced with 100mg/kg dose and significantly reduced with 200mg/kg dose. The 70% ethanolic extract of leaves of the plant possess antiulcer properties. The antiulcer properties of the extract may be attributed to the polyphenolic compounds that are present in it.

Keywords: Albizzia lebbeck; Antiulcer; indomethacin