Phytophenolics from Peltophorum africanum Sond. (Fabaceae) with promising hepatoprotective activity

Abstract

The aqueous alcoholic extract of Peltophorum africanum Sond. (Fabaceae) exhibited hepatoprotective activity represented by significant reduction of elevated serum liver enzymes and significant reduction in hepatic TBARS levels in hepatotoxicated animals. Fifteen known phenolic metabolites were identified for the first time from the entitled plant. Establishment of all structures were based on conventional methods of analysis, ESI/MS, in addition, complete 1H and 13C NMR assignments were obtained for the isolated compounds. Their structures were elucidated to be; gallic acid 1, 3-O-methyl gallic acid 2, quercetin-3-O-1C4-α-L-rhamnopyranosyl-(1'''→6'')-4C1-β-D-glucopyranoside, rutin 3, kaempferol-3-O-1C4-α-L-rhamnopyranosyl-(1'''→6'')-4C1-β-D-glucopyranoside, nicotiflorin 4, kaempferol-3-O-4C1-β-D-glucoside, astralagin 5, quercetin-3-O-4C1-β-D-glucoside, isoquercitrin 6, methyl 3,4,5-trihydroxybenzoate, methyl gallate 7, kaempferol-3-O-(6''-O-galloyl)-4C1-β-D-galactopyranoside 8, quercetin-3-O-(6''-O-galloyl)-4C1-β-D-galactopyranoside 9, myricetin-3-O-(6''-O-galloyl)-4C1-β-D-galactopyranoside 10, (-)-epigallocatechin-3-O-gallate 11, (+)-gallocatechin-3-O-gallate 12, myricetin 13, quercetin 14, kaempferol 15.

Keywords: Peltophorum africanum; Fabaceae; hepatoprotective; Phenolics