Article · Volume 5, Issue 17 · pp. 28–36
Chemical Composition and Hepato-protective activity of Imperata cylindrica Beauv.
Gamal A. Mohamed1, Ahmed Abdel-Lateff2, Mostafa A. Fouad3, Sabrin R. M. Ibrahim4, Ehab S. Elkhayat4, Tatsufumi Okino4
- 1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
- 2Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
- 3Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
- 4Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan.
Abstract
Phytochemical study of the aerial parts of Imperata cylindrica Beauv. (Graminae), growing in Egypt afforded four methoxylated flavonoids 1-4, β-sitosterol-3-O-β-D-glucopyranosyl-6´-tetradecanoate 5, 3-hydroxy-4-methoxy-benzaldehyde 6, together with daucosterol, β-sitosterol and α-amyrin 7-9. To the best of our knowledge, this is the first isolation of compounds 1-5 from the genus Imperata. A significant hepato-protective activity had been observed upon co-administration of the methanolic extracts of I. cylindrica with CCl4. The structures were determined using spectroscopic data; 1D (1H and 13C), 2D (HSQC, and HMBC) NMR; MS; UV and IR.
Keywords: Methoxylated flavonoids; Imperata cylindrica; steroids; hepato-protective activity
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